Tuesday, 11 April 2017

Evidence on the analgesic role of bisphosphonates and denosumab in the treatment of pain due to bone metastases: A systematic review within the European Association for Palliative Care guidelines project

Palliative Medicine, 2017, 31(1) 5-25
Porta-Sales, Josep; Garzón-Rodríguez, Cristina; Llorens-Torromé, Silvia; Brunelli, Cinzia; Pigni, Alessandra; Caraceni, Augusto

The aims of this review were to appraise the evidence for the efficacy and safety of biphosphonates and denosumab in controlling pain and the appropriate schedule of administration.  The authors found that the evidence to support an analgesic role is weak but that they do appear to be helpful in delaying the onset of bone pain. 

Fulltext available in Palliative Medicine
Available in print in the Arthur Rank Hospice Library, Cambridge