Candy B, Jones L, Vickerstaff V, Larkin PJ, Stone P.
Update of 2 Cochrane reviews identified 4 new trials.
Conclusions for naldemedine are new, suggesting that taken orally, it improves
bowel function over 2 weeks but increases risk of adverse events. Conclusions
on naloxone and methylnaltrexone have not changed.
Fulltext available from the Cochrane Library