Supportive Care in Cancer, May 2015, 23(5):1473-81
Afsharimani B; Kindl K; Good P; Hardy J.The management of patients with refractory pain remains a challenge. The evidence of benefit for many of the agents used is weak, and each additional agent increases the risk of adverse events. Evidence-based guidelines cannot, therefore, be developed at present. New approaches are recommended including targeted opioid therapy, multimodal analgesia, a goal-oriented approach to pain management and increasing use of the multidisciplinary team and support services.
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