Wednesday 30 March 2016

Malignancy associated hypercalcaemia-responsiveness to IV bisphosphonates and prognosis in a palliative population

Supportive Care in Cancer, April 2016, vol./is. 24/4(1771-1777)
Mallik S., Mallik G., Macabulos S.T., Dorigo A.

The goals of this study were to determine the reversibility of hypercalcaemia amongst patients whose underlying malignancy is not being treated and assess whether correction results in improvement in symptoms attributable to hypercalcaemia, while identifying risk factors that can predict responsiveness.  The authors found that a reduction in calcium level was associated with a significantly prolonged survival, as well as symptomatic improvement, irrespective of whether normocalcaemia was achieved.