Wednesday 20 June 2018

A critical appraisal of gabapentinoids for pain in cancer patients

Current Opinion in Supportive and Palliative Care, 2018 12(2) p108-117
Jordan, Roberta I; Mulvey, Matthew R; Bennett, Michael I

This review summarizes recent randomised controlled trials (RCTs) evaluating the use of gabapentinoids for tumour-related and treatment-related pain.  Many of the studies included were limited by small sample size, lack of blinding, and inadequate follow-up.  The authors therefore conclude that more and better quality studies are required but that gabapentinoids may offer benefits to cancer patients with pain, but that careful titration and monitoring of adverse effects is necessary.